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National Center for PTSD

Psychopharmacological Treatment of PTSD

Satellite Broadcast
Original Air Date 01/23/02
90 minutes

Speaker:
Steven E. Lindley, M.D., Ph.D.
Associate Director for Research, National Center for PTSD, VA Palo Alto Health Care System, Palo Alto CA

Overview:
The purpose of this broadcast is to increase participants' knowledge in identifying target symptoms in PTSD for pharmacological treatment and to provide basic information on the mechanisms of action of various classes of pharmacological agents. Also the presentation will review data on the efficacy of various classes of medications in treatment of PTSD.

Goals:
After the completion of this program, participants should be able to:

  1. describe the hypothesized mechanism of action of the major classes of pharmacological agents; and
  2. know what medications have objective data supporting their efficacy in the treatment of PTSD.

Part 1: Introduction (14:19)

Review of the symptoms of PTSD and associated co-morbid conditions
  RealPlayer, 6161 kb
Quicktime Low-Bandwidth, 8847 kb
Quicktime Medium, 13257 kb
Quicktime Hi-Bandwidth, 21538 kb
Windows Media Low-Bandwidth, 7190 kb
Windows Media Hi-Bandwidth, 20983 kb

Part 2: Neurotransmitter Review (4:06)

Review of the neurochemical communication
  RealPlayer, 1784 kb
Quicktime Low-Bandwidth, 2488 kb
Quicktime Medium, 3549 kb
Quicktime Hi-Bandwidth, 5743 kb
Windows Media Low-Bandwidth, 2112 kb
Windows Media Hi-Bandwidth, 6088 kb

Part 3: Overview of Pharmacological Treatment (13:59)

Classes of Agents; Tricyclic Antidepressants, MAO, TCAs, SSRIs, Fluoxetine, Sertraline
  RealPlayer, 5998 kb
Quicktime Low-Bandwidth, 8303 kb
Quicktime Medium, 12060 kb
Quicktime Hi-Bandwidth, 19329 kb
Windows Media Low-Bandwidth, 6906 kb
Windows Media Hi-Bandwidth, 20225 kb

Part 4: Efficacy; Antidepressants(12:16)

Factors for reported lack of efficacy in VA population; Paroxetine, Sertraline, Nefazodone; Summary of anti-depressants
  RealPlayer, 5253 kb
Quicktime Low-Bandwidth, 7469 kb
Quicktime Medium, 11101 kb
Quicktime Hi-Bandwidth, 17830 kb
Windows Media Low-Bandwidth, 6294 kb
Windows Media Hi-Bandwidth, 18078 kb

Part 5: More Agents; Recommendations (21:56)

Anticonvulsants, Benzodiazepines, Antiadrenergic Agents, Antipsychotics; Recommendations; Future agents
  RealPlayer, 9410 kb
Quicktime Low-Bandwidth, 13265 kb
Quicktime Medium, 19334 kb
Quicktime Hi-Bandwidth, 31339 kb
Windows Media Low-Bandwidth, 11296 kb
Windows Media Hi-Bandwidth, 32262 kb

Part 6: Questions and Answers session (27:27)

  RealPlayer, 11798 kb
Quicktime Low-Bandwidth, 17195 kb
Quicktime Medium, 26451 kb
Quicktime Hi-Bandwidth, 42450 kb
Windows Media Low-Bandwidth, 14115 kb
Windows Media Hi-Bandwidth, 40172 kb